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Cops2 Gene Detail
Summary
  • Symbol
    Cops2
  • Name
    COP9 signalosome subunit 2
  • Synonyms
    alien homologue, alien-like, Csn2, Sgn2, Trip15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330276
    NCBI Gene: 12848
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:125672222-125701002 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    691 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330276
 protein coding gene Chr2:125672222-125701059 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026434
 protein coding gene Chr2:129040953-129071330 (-)
A/J MGP_AJ_G0026397
 protein coding gene Chr2:123783972-123813750 (-)
AKR/J MGP_AKRJ_G0026373
 protein coding gene Chr2:127320302-127348633 (-)
BALB/cJ MGP_BALBcJ_G0026409
 protein coding gene Chr2:124073093-124101970 (-)
C3H/HeJ MGP_C3HHeJ_G0026153
 protein coding gene Chr2:127804732-127833327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026855
 protein coding gene Chr2:133145183-133175535 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024232
 protein coding gene Chr2:118565998-118594614 (-)
CAST/EiJ MGP_CASTEiJ_G0025614
 protein coding gene Chr2:128060564-128087962 (-)
CBA/J MGP_CBAJ_G0026133
 protein coding gene Chr2:137971528-138001258 (-)
DBA/2J MGP_DBA2J_G0026267
 protein coding gene Chr2:123196901-123226411 (-)
FVB/NJ MGP_FVBNJ_G0026231
 protein coding gene Chr2:121884484-121914128 (-)
LP/J MGP_LPJ_G0026372
 protein coding gene Chr2:129265942-129295687 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026251
 protein coding gene Chr2:142085661-142117045 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026910
 protein coding gene Chr2:127358904-127387838 (-)
PWK/PhJ MGP_PWKPhJ_G0025350
 protein coding gene Chr2:122738340-122767464 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025152
 protein coding gene Chr2:126441655-126476412 (-)
WSB/EiJ MGP_WSBEiJ_G0025688
 protein coding gene Chr2:128262370-128293536 (-)



Homology
more
  • Human Ortholog
    COPS2, COP9 signalosome subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS2, COP9 signalosome subunit 2
  • Synonyms
    ALIEN, CSN2, SGN2, TRIP15
  • Links
    NCBI Gene ID: 9318
    neXtProt AC: NX_P61201
    UniProt: P61201

  • Chr Location
    15q21.1; chr15:49106068-49155661 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos very soon after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    135
  • cDNA Data
    212
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12848 NCBI Gene Model | MGI Sequence Detail 28781 C57BL/6J ±  kb
    transcript NM_001285512 RefSeq | MGI Sequence Detail 3380 ZRU/MplStud  
    polypeptide P61202 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005739 COP9 signalosome complex subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR050871 26S Proteasome and COP9 Signalosome Components
      IPR000717 Proteasome component (PCI) domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
    • GlyGen
      P61202 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 214
      Genomic 1
      cDNA 212
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138892, MGI:2139517
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:317457 Lin H, et al., IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Nat Commun. 2021 Apr 28;12(1):2461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory